Journal article
VIVID: A Web Application for Variant Interpretation and Visualization in Multi-dimensional Analyses
S Tichkule, Y Myung, MT Naung, BRE Ansell, AJ Guy, N Srivastava, S Mehra, SM Cacciò, I Mueller, AE Barry, C Van Oosterhout, B Pope, DB Ascher, AR Jex
Molecular Biology and Evolution | OXFORD UNIV PRESS | Published : 2022
Abstract
Large-scale comparative genomics- and population genetic studies generate enormous amounts of polymorphism data in the form of DNA variants. Ultimately, the goal of many of these studies is to associate genetic variants to phenotypes or fitness. We introduce VIVID, an interactive, user-friendly web application that integrates a wide range of approaches for encoding genotypic to phenotypic information in any organism or disease, from an individual or population, in three-dimensional (3D) space. It allows mutation mapping and annotation, calculation of interactions and conservation scores, prediction of harmful effects, analysis of diversity and selection, and 3D visualization of genotypic inf..
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Awarded by State Government of Victoria
Funding Acknowledgements
This work was supported by the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme to A.R.J and D.B.A. This work was supported by the National Health and Medical Research Council investigator grant (APP1194330) to A.R.J. This work was supported by the National Health and Medical Research Council investigator grant (GNT1174405) to D.B.A. This work was supported by a Victorian Health and Medical Research Fellowship from the Victorian State Government to B.P. This work was supported by an NHRMC Principal Research Fellowship (GNT1155075) to I.M. A.J.G. was supported by a Vice-Chancellor's Postdoctoral Research Fellowship from RMIT University. S.T. was supported by a Walter and Eliza Hall International PhD Scholarship. S.T., Y.M., and M.T.N were further supported by a Melbourne Research Scholarship.